Why is it in the news?
A new study found that to escape the drug Lenacapavir, HIV must damage its own capsid.
Reaffirms viral capsid as an effective target for antiviral therapy.
Category: Science and Technology
Important Points:
● Three-dimensional proteinaceous shell enclosing viral genetic material
● Located just below the viral envelope
● Made of repeating protein subunits called capsomeres or protomers
● Capsomeres may be closely associated with viral nucleic acid
● Capsid complexity depends on virus’s genetic material
● Some complex viruses have non-protein components like lipids
● Enveloped capsids are further enclosed in glycoprotein layer
● Exists in nanometer (nm) size range with unique mechanical properties
● Functions include protecting and transferring viral genetic material